The interaction between matter and antimatter produces energy in the
form of radiation, that is equal with the energy of the two initial particles.
You can calculate a particle energy from the equation : E = m * c^2,
where the m is the mass of the particle when it is still, and E=rest energy
Say you have an electron and a positron. Each of them has rest energy 0.51 MeV.
Their interaction would give a photon that has energy 2*0.51 MeV= 1.02 MeV
You can do the same for any other particle-antiparticle couple.
Theoretically, if there is nothing to interact with, antimatter could exist forever.
Absolute vacuum is a theoretical concept though. It can't be created in lab and
neither be observed in some experimental way as the observation itself
contains at least electromagnetic waves.
So the answer is based on theory and not experiment.
You can read an interesting theory, called "Dirac sea", on the creation of
matter-antimatter in absolute vacuum.